Think that all raw NMR data should be required for publication of natural product structures? We do, and so do 71 other scientists in the field. Check out Joe's latest paper in Natural Product Reports where we contributed a section to a large review on the value and need for raw NMR data to support transparent and accurate research in this area.
Dennis and Jessie have been collaborating with the Payne group in Australia to screen a series of natural product analogues synthesized by their team. The results of the synthesis and screening have just appeared in Organic and Biomolecular Chemistry. Congratulations to the whole team!
Today our first collaborative paper with the Gries and Britton groups was published in Angewandte Chemie, describing the discovery of the first sex attractant in Vespid insects. Congratulations to joint first authors Weiwu, Cat and Nathan on what we hope will be the first of many joint projects in this area. This was a fascinating project, requiring detailed and careful work in the areas of chemical ecology, analytical chemistry and synthesis. A perfect example of interdisciplinary research at SFU!
The full paper describing the total synthesis of the skyllamycins and simplified analogues by the Payne group, and our analytical and biological characterization of these products is out today in the Journal of Organic Chemistry. Well done to Jake, Kenji and the Payne team on this nice result.
The next manuscript from out longstanding collaboration with the Yildiz lab at UCSC is published today in the Canadian Journal of Chemistry. This article is part of a special issue celebrating 50 years of chemistry at SFU. Well done to all involved.
Congratulations to Cat, who was one of the winners of the annual SFU Department of Chemistry poster competition. Cat's presentation about stable isotope labeling for identifying the products of biosynthetic gene clusters earns her $1000 to put towards conference registration this summer.
Jessie Ochoa's major new paper describing the discovery of a novel antibiotic from the porpoise microbiome appears today in ACS Infectious Diseases. This work was a multidisciplinary effort between our lab and the labs of K.C. Huang (Stanford) and Carol Gross (UCSF). Congratulations to all participants on an outstanding piece of work.
Two of our collaborative papers with the Payne group in Australia have been published today. Firstly, Jessie's screening contribution to the total synthesis of glycinocins A - C was published in JOC. Secondly, Jake and Kenji's analytical and screening contributions to the total synthesis of skyllamycins A - C was published in Chemistry - A European Journal. Two terrific outcomes from our ongoing collaboration with our Australian colleagues!
A warm welcome to our three newest graduate students- Nicole LeGrow, Jason McFarlane and Darryl Wilson, who is a joint student with the Britton lab. Maybe now the boss should update the pictures page (!)
Marty Burke and his team from the University of Illinois at Urbana-Champaign have written a nice commentary in PNAS on our recent article there. Check it out from this reference:
PNAS 2017 114 (22) 5564-5566; published ahead of print May 22, 2017, doi:10.1073/pnas.1706266114
Nobody outside our lab will care about this news article, but it really matters to our team!
After a heroic struggle, the Speedvac is fixed.
Kenji and Cat tried...
even the Boss tried!
Finally it is back in action. Now back to work!
Our latest work describing our meta-analysis of all previously published NP structures from the microbial and marine worlds, has been published this afternoon. The work, which is a collaborative project with colleagues at UCSD and UCSC, describes our efforts to examine rates of novel natural product discovery over time, and the value of examining different source organisms for novel compound discovery.
The latest results from our ongoing collaboration with the Payne group at the University of Sydney were published today in Nature Communications. Congratulations to the Payne group and everyone involved for the successful completion of a fascinating study.
Congratulations to Jake, who is one of the winners for the 2017 SFU Department of Chemistry poster competition. This award provides financial support to help Jake attend the 2017 ASP conference in Portland.
The Linington lab is looking for talented enthusiastic candidates for a new postdoctoral position at the interface of natural products and integrated Omics. Interested parties are encouraged to check out the flyer on the Opportunities page for more details.
The GNPS paper describing the development of a new open access platform for MS2 fingerprinting of natural products is published today in Nature Biotechnology. Led by Pieter Dorrestein and Nuno Banderia from UCSD, this project involved both our current postdoc Kenji Kurita, and one of our former graduate students, Laura Sanchez. Congratulations to all for a beautiful piece of work.
The lab has been featured among a number of groups interested in cytological profiling in a news article in this week's edition of Science. Those with a subscription can read the original article here:
Jessie's collaboration with the Payne group from the University of Sydney in Australia has just been published in Organic Letters. Jessie provided screening data to support their report of the first total synthesis of the much lauded new natural product antibiotic teixobactin. Well done to all.
Bob and Bailey's collaboration with Kerstin Effenberger from Melissa Jurica's lab looking for natural product inhibitors of splicing has just been published in JBC. Congratulations to all on an interesting and exciting collaborative effort.
Jessie's first manuscript, describing the use of cytological profiling to explore our natural products library for compounds with specific phenotypes, is out today as an ASAP article in JNP. Congratulations to Jessie!
Professor Linington and the Linington Lab have moved after eight wonderful years at the University of California Santa Cruz to take up a new position as a Canada Research Chair in High-Throughput Screening and Chemical Biology in the Department of Chemistry at Simon Fraser University. Please come and visit us if you are in the Vancouver area, and see our new labs, equipment and colleagues.
Our first collaborative project with the Derisi lab at UCSF focused on antimalarial drug discovery has just been published in the Journal of Organic Chemistry. Congratulations to joint lead authors Chris, Gabe and Danny Ebert.
Chris Schulze's collaboration with Mohamed Donia and Michael Fischbach describing a systematic evaluation of the biosynthetic capacity of bacteria from the human microbiome has just been published in Cell. Congratulations to all!
This manuscript describes the use of Clusterfinder (a new computational method for the unbiased discovery of natural product biosynthetic gene clusters (BGCs) from genomic data) to characterize global biosynthetic capacity of the bacterial and archeal kingdoms. Kenji's contribution focused on the isolation and identification of the product of a pair of widely distributed but previously uncharacterized BGCs. Congratulations to Kenji and the Fischbach team for the publication of a landmark paper!
Dr. Linington has been selected as the American Society of Pharmacognosy 2014 Matt Suffness Young Investigator award winner. As part of this award he will be presenting the Suffness award lecture at the upcoming ASP annual meeting in Oxford, Mississippi in July 2014.
Our collaborator Dr. Sarah Higginbotham, who was the lead researcher on the sloth fur microbiome study, has been featured on the radio on the CBC show 'Quirks and Quarks'. You can listen to her interview here:
Our latest paper, which was a contribution to a project led by Dr. Sarah Higginbotham from the Smithsonian Tropical Research Institute in Panama, describes her work on the discovery of novel fungal diversity from sloth fur, and the profiles of some of the extracts from this collection in our BioMAP screening assay system. This is part of the Panama ICBG program, which our lab has been part of for the last 7 years. Check it out here.
We have two separate articles coming out in the February issue of Antimicrobial Agents and Chemotherapy- one with our collaborator Vicki Auerbuch Stone on the discovery of novel type III secretion system inhibitors, and one with Prof. Fitnat Yildiz, also from the METOX department at UCSC, focused on the development of an image-based screen for finding novel inhibitors of biofilm formation in Pseudomonas aeruginosa.