2017

66. Corcilius, L.; Elias, N. T.; Ochoa, J. L.; Linington, R. G.; Payne, R. J.* "Total Synthesis of Glycinocins A - C.", Journal of Organic Chemistry, 2017, ASAP.
65. Giltrap, A. M.; Haeckl, F. P. J.; Kurita, K. L.; Linington, R. G.; Payne, R. J.* "Total Synthesis of Skyllamycins A - C." Chemistry - A European Journal, 2017, ASAP.
64. Caicedo, J. C.; Cooper, S.; Heigwer, F.; Warchal, S.; Qiu, P.; Molnar, C.; Vasilevich, A. S.; Barry, J. D.; Bansal, H. S.; Kraus, O.; Wawer, M.; Paavolainen, L.; Herrmann, M. D.; Rohban, M.; Hung, J.; Hennig, H.; Concannon, J.; Smith, I.; Clemons, P. A.; Singh, S.; Rees, P.; Horvath, P.; Linington, R. G.; Carpenter, A. E.* "Data-Analysis Strategies for Image-Based Cell Profiling." Nat. Meth. 2017, 14, 849–863.
63. Pye, C.; Bertin, M.; Lokey, R. S.; Gerwick, W. H.*; Linington, R. G.* "Reply to Skinnider and Magarvey: Rates of novel natural product discovery remain high." Proceedings of the National Academy of Sciences, USA, 2017, ASAP.
62. Pye, C.; Bertin, M.; Lokey, R. S.; Gerwick, W. H.*; Linington, R. G.* "Retrospective Analysis of Natural Products Provides Insights for Future Discovery Trends" Proceedings of the National Academy of Sciences, USA, 2017, 114, 5601 - 5606.
61. Cichewicz, R. H.; Cragg, G. M.; Linington, R. G.; Wright, A. E. "Special Issue in Honor of Professor Phil Crews" Journal of Natural Products, 2017, 80, 579 - 581
60. Tran, A. T.; Watson, E. E.; Pujari, V.; Conroy, T.; Dowman, L. J.; Giltrap, A. M.; Pang, A.; Wong, W.-R.; Linington, R. G.; Mahapatra, S.; Saunders, J.; Charman, S. A.; West, N. P.; Bugg, T. D. H.; Tod, J.; Dowson, C. G.; Roper, D. I.; Crick, D. C.; Britton, W. J.; Payne, R. J..* "Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis" Nature Communications, 2017, 8, Article number: 14414
59. Morgan, J. M.; Duncan, M. C.; Johnson, K. S.; Diepold, A.; Lam, H.; Dupzyk, A. J.; Martin, L. R.; Wong, W.-R.; Armitage, J. P.; Linington, R. G.; Auerbuch, V.* "Piericidin A1 blocks Yersinia Ysc type III secretion system needle assembly" mSphere, 2017, 2:e00030-17.

2016

58. Harms, H.; Kurita, K. L.; Pan, L.; Wahome, P. G.; He, H.; Kinghorn, A. D.; Carter, G. T.; Linington, R. G.* "Discovery of Anabaenopeptin 679 From Freshwater Algal Bloom Material: Insights Into the Structure-Activity Relationship of Anabaenopeptin Protease Inhibitors" Bioorganic and Medicinal Chemistry Letters, 2016, 26, 4960-4965.
57. Wang, M.; Carver, J. J.; Phelan, V. V.; Sanchez, L. M.; Garg, N. et al (113 others) "Sharing and Community Curation of Mass Spectrometry Data with Global Natural Products Social Molecular Networking" Nature Biotechnology, 2016, 34, 828-837.
56. Giltrap, A. M.; Dowman, L. J.; Nagalingam, G.; Ochoa, J. L.; Linington, R. G.; Britton, W. J.; Payne, R. J.* "Total Synthesis of Teixobactin." Organic Letters, 2016, 18, 2788–2791.
55. Sanchez, L. M.; Cheng, A. T.; Warner, C. J. A.; Townsley, L.; Peach, K. C.; Navarro, G.; Shikuma, N. J.; Bray, W. M.; Riener, R. M.; Yildiz, F. H.; Linington, R. G.* "Biofilm Formation and Detachment in Gram-Negative Pathogens Is Modulated by Select Bile Acids." PLOS ONE, 2016, 11, e0149603.

2015

54. Effenberger, K. A.; James, R. C..; Urabe, V. K.; Dickey, B. J.; Linington, R. G.*, Jurica, M. S.* "The Natural Product N-palmitoyl-L-leucine Selectively Inhibits Late Assembly of Human Spliceosomes." Journal of Biological Chemistry, 2015, 290, 27524 - 27531. PMID: 26408199
53. Kurita, K. L.; Glassey, E.; Linington, R. G.* "Integration of High-Content Screening and Untargeted Metabolomics for Comprehensive Functional Annotation of Natural Product Libraries." Proceedings of the National Academy of Sciences, USA, 2015, 112, 11999-12004. PMID: 26371303
52. Ochoa, J. L.; Bray, W. M.; Lokey, R. S.; Linington, R. G.* "Phenotype-Guided Natural Products Discovery Using Cytological Profiling." Journal of Natural Products, 2015, 78, 2242-2248. PMID: 26292657
51. Schulze, C. J.; Donia, M. S.; Siqueira-Neto, J. L.; Ray, D.; Raskatov, J. A.; Green, R. E.; McKerrow, J. H.; Fischbach, M. A.; Linington, R. G.* "Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei." ACS Chemical Biology, 2015, 16, 2373 - 2381. PMID: 26270237
50. Shao, C. L.; Linington, R. G.; Balunas, M. J.; Centeno, A.; Boudreau, P.; Zhang, C.; Engene, N.; Spadafora, C.; Mutka, T. S.; Kyle, D. E.; Gerwick, L.; Wang, C. Y.; Gerwick, W. H.* “Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta.” Journal of Organic Chemistry, 2015, 80, 6849-7855. PMID: 26222145
49. León, B.; Haeckl, F. J.; Linington, R. G.* “Optimized Quinoline Amino Alcohols as Disruptors and Dispersal Agents of Vibrio cholerae Biofilms.” Organic and Biomolecular Chemistry, 2015, 13, 8495 - 8499. PMID: 26156292
48. Teschler, J. K.; Zamorano-Sánchez, D.; Utada, A. S.; Warner, C. J. A.; Wong, G. C. L.; Linington, R. G.; Yildiz F. H.* “Living in the Matrix: Assembly and Control of Vibrio cholerae biofilms” Nature Reviews Microbiology, 2015, 13, 255 - 268. PMID: 25895940
47. Kurita, K. L.; Linington, R. G.* “Connecting Phenotype and Chemotype: High-Content Discovery Strategies for Natural Products Research” Journal of Natural Products, 2015, 78, 587 - 596. PMID: 25728167
46. Schulze, C. J.; Navarro, G.; Ebert, D.; DeRisi, J.*; Linington, R. G.* “Salinipostins A−K, Long-Chain Bicyclic Phosphotriesters as a Potent and Selective Antimalarial Chemotype” Journal of Organic Chemistry, 2015, 80, 1312-1320. PMID: 25584395
45. León, B.; Navarro, G.; Dickey, B. J.; Stepan, G.; Tsai, A.; Jones, G. S.; Morales, M. E.; Barnes, T.; Ahmadyar, S.; Tsiang, M.; Geleziunas, R.; Cihlar, T.; Pagratis, N.; Tian, Y.; Yu, H.; Linington, R. G.* “Abyssomicin 2 Reactivates Latent HIV‐1 by a PKC- and HDAC- Independent Mechanism” Organic Letters, 2015, 15, 262-265. PMID: 25560385
44. Warner, C. J. A; Cheng, A. T.; Yildiz, F. H.; Linington, R. G.* “Development of Benzo[1,4]oxazines as Biofilm Inhibitors and Dispersal Agents Against Vibrio cholerae ChemComm, 2015, 51, 1305-1308. PMCID: PMC4288701

2014

43. Schulze, C. J.; Bray, W. M.; Loganzo, F.; Lam, M.-H.; Szal, T.; Villalobos, A.; Koehn, F.; Linington, R. G.* “Borrelidin B: Isolation, Biological Activity, and Implications for Nitrile Biosynthesis” J. Nat. Prod., 2014, 77, 2570-2574. PMID: 25393949
42. Donia, M.; Cimermancic, P.; Schulze, C. J.; Wieland Brown, L. C.; Martin, J.; Makedonka, M.; Clardy, J.; Linington, R. G.; Fischbach, M. A.* “A Systematic Analysis of Biosynthetic Gene Clusters in the Human Microbiome Reveals a Common Family of Antibiotics” Cell, 2014, 158, 1402-1414. PMCID: PMC4164201
41. Cimermancic, P.; Medema, M. H.; Claesen, J.; Kurita, K.; Wieland Brown, L. C.; Mavrommatis, K.; Pati, A.; Godfrey, P. A.; Koehrsen, M.; Clardy, J.; Birren, B. W.; Takano, E.; Sali, A.; Linington, R. G.; Fischbach, M. A.* “Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters” Cell, 2014, 158, 412-421. PMCID: PMC4123684
40. Schulze, C. J. and Linington, R. G. (2014) "Image-Based Screening Approaches to Natural Products Discovery." In A. Osbourn, R. Goss & G.T. Carter (Eds.) Natural Products: Discourse, Diversity, and Design (pp. 373-396) New York, NY: Wiley.
39. Higginbotham, S.*; Wong, W. R.; Linington, R. G.; Spadafora, C.; Iturrado, L.; Arnold, E. A."Sloth Hair as a Novel Source of Fungi with Potent Anti-Parasitic, Anti-Cancer and Anti-Bacterial Bioactivity." PLoS ONE 2014 9(1): e84549. PMCID: PMC3893167
38. Duncan, M. C.; Wong, W. R.; Dupzyk, A. J.; Bray, W. M.; Linington, R. G.; Auerbuch V.* "An NF-κB-Based High Throughput Screen Identifies Piericidins as Inhibitors of the Yersinia pseudotuberculosis Type III Secretion System." Antimicrob. Agents Chemother. 2014, 58, 1118-1126. PMCID: PMC3910828
37. Navarro, G.; Cheng, A. T.; Peach, K. C.; Bray, W. M.; Bernan, V. S.; Fitnat H. Yildiz, F. H.; Linington R. G.* "An Image-Based 384-Well High-Throughput Screening Method for the Discovery of Skyllamycins A - C as Biofilm Inhibitors and Inducers of Biofilm Detachment in Pseudomonas aeruginosa" Antimicrob. Agents Chemother. 2014, 58, 1092-1099. PMCID: PMC3910817
36. Liu, W.-T.; Lamsa, A.; Wong, W. R.; Boudreau, P. D.; Kersten, R.; Peng, Y.; Moree, W. J.; Duggan, B. M.; Moore, B. S.; Gerwick, W. H.; Linington, R. G.; Pogliano, K.; Dorrestein, P. C. "MS/MS-Based Networking and Peptidogenomics Guided Genome Mining Revealed the Stenothricin Gene Cluster in Streptomyces roseosporus" The Journal of Antibiotics 2014, 67, 99-104. PMCID: PMC3919142

2013

35. Peach, K. C.; Cheng, A. T.; Oliver, A. G.; Yildiz, F. H.; Linington, R. G.* "Discovery and Biological Characterization of the Auromomycin Chromophore as an Inhibitor of Biofilm Formation in V. cholerae" ChemBioChem 2013, 14, 2209 - 2215. PMCID: PMC3947468
34. Jane Y. Yang, J. Y.; Sanchez, L. M.; Rath, C. M.; Liu, X.; Boudreau, P. D.; Bruns, N.; Glukhov, E.; Wodtke, A.; De Felicio, R.; Fenner, A.; Wong, W.- R.; Linington, R. G.; Zhang, L.; Debonsi, H. M.; Gerwick, W. H.; Dorrestein P. C.* "Molecular Networking as a Dereplication Strategy" Journal of Natural Products 2013, 76, 1686 - 1699. PMCID: PMC3936340
33. Peach, K. C.; Bray, W. M.; Winslow, D. Linington, P. F.; Linington, R. G.* "Mechanism of Action-Based Classification of Antibiotics using High-Content Bacterial Image Analysis Molecular Biosystems 2013, 9, 1837 - 1848. PMCID: PMC3674180
32. León, B.; Fong, J. C. N.; Peach, K. C.; Wong, W.-R.; Yildiz, F. H.; Linington, R. G.* "Development of Quinoline-Based Disruptors of Biofilm Formation Against Vibrio cholerae" Organic Letters 2013, 15, 1234 – 1237. PMID: 23461487
31. Sanchez, L. M.; Knudsen, G. M.; Helbig, C.; De Muylder, G.; Mascuch, S. M.; Mackey, Z. B.; Gerwick, L.; Clayton, C.; McKerrow, J. H.; Linington, R. G.* “Examination of the Mode of Action of the Almiramide Family of Natural Products against the Kinetoplastid Parasite Trypanosoma brucei" Journal of Natural Products 2013, 76, 630 – 641. PMCID: PMC3971013
30. Schulze, C. J.; Bray, W. M.; Woerhman, M. H.; Stuart, J.; Lokey, R. S.; Linington, R. G.* "‘‘Function-First’’ Lead Discovery: Mode of Action Profiling of Natural Product Libraries Using Image- Based Screening" Chemistry and Biology 2013, 20, 285-295. PMCID: PMC3584419

2012

29. Wong, W.-R.; Oliver, A. G.; Linington, R. G.* "Development of BioMAP Screening for the Classification and Discovery of Natural Product Antibiotics" Chemistry and Biology 2012, 19, 1483-1495. PMID: 23177202
28. Carlile, G. W.; Keyzers, R. A.; Teske, K. A.; Robert, R.; Williams, D. E.; Linington, R. G.; Gray, C. A.; Centko, R. M.; Yan, L.; Anjos, S. M.; Sampson, H. M.; Zhang, D.; Liao, J.; Hanrahan, J. W.; Andersen, R. J.; Thomas, D. Y.* "Correction of F508del-CFTR trafficking by the sponge alkaloid latonduine is modulated by interaction with PARP" Chemistry and Biology 2012, 19, 1288-1299. PMID: 23102222
27. Navarro, G.; Chokpaiboon, S.; De Muylder, G.; Bray, W. M.; Nisam, S. C.; McKerrow, J. H.; Pudhom, K.; Linington, R. G.*, "Hit-to-Lead Development of the Chamigrane Endoperoxide Merulin A for the Treatment of African Sleeping Sickness" PLoS ONE 2012, 9, e46172. PMCID: PMC3459870
26. Duncan, M. C.; Linington, R. G.; Auerbuch, V.* "Chemical inhibitors of the type three secretion system: disarming bacterial pathogens" Antimicrobial Agents and Chemotherapy, 2012, 56, 5433-5441. PMCID: PMC3486574
25. Sanchez, L. M.; Wong, W. R.; Riener, R. M.; Schulze, C. J.; Linington, R. G.* “Examining the Fish Microbiome: Vertebrate-Derived Bacteria as an Environmental Niche for the Discovery of Unique Marine Natural Products” PLoS ONE 2012, 7, e35398. PMCID: PMC3344833

2011

24. White, T. R; Renzelman, C. M.; Rand, A. C.; Rezai, T.; Mcewen, C. M.; Gelev, V. M.; Turner, R. A.; Linington, R. G.; Leung, S. S. F.; Kalgutkar, A. S.; Bauman, J. N.; Zhang, Y.; Liras, S.; Price, D. A.; Mathiowetz, A. M.; Jacobson, M. P.*; Lokey, R. S.* "On-resin n-methylation of cyclic peptides for discovery of orally bioavailable scaffolds" Nat. Chem. Bio. 2011, 7, 810 - 817. PMCID: PMC3210067
23. Conroy, T.; Guo, J. T.; Linington, R. G.; Hunt, N. H.; Payne, R. J.* "Total Synthesis, Stereochemical Assignment, and Antimalarial Activity of Gallinamide A" Chem. Eur. J. 2011, 17, 13544-13552. PMID: 22006835
22. Radjasa, O.K.; Vaske, Y.M.; Navarro, G.; Vervoort, H.C.; Tenney, K.; Linington, R.G.; Crews, P.* "Highlights of marine invertebrate-derived biosynthetic products: their biomedical potential and possible production by microbial associants." Bioorg. Med. Chem. 2011, 19, 6658-6674. PMCID: PMC3205244
21. Nunnery, J. K.; Suyamaa, T. L.; Linington, R. G.; Gerwick, W. H.* "Expedient synthesis of α,α-dimethyl-β-hydroxy carbonyl scaffolds via Evans’ aldol reaction with a tertiary enolate" Tet. Lett. 2011, 52, 2929-2932. PMCID: PMC3100194
20. Sanchez, L. M.; Curtis, M. E.; Bracamonte, B. E.; Kurita, K. L.; Navarro, G.; Sparkman, O. D.; Linington, R. G.* "Versatile method for the detection of covalently bound substrates on solid supports by DART mass spectrometry" Org. Lett. 2011, 13, 3770-3773. PMCID: PMC3146587
19. Peach, K. C.; Bray, W. M.; Shikuma, N. J.; Gassner, N. C.; Lokey, R. S.; Yildiz, F. H.; Linington, R. G.* "An image-based 384-well high-throughput screening method for the discovery of biofilm inhibitors in Vibrio cholerae" Mol. Biosyst. 2011 1176 – 1184. PMID: 21246108

2010

18. Liu, X.; Beyhan, S.; Lim, B.; Linington, R. G.; Yildiz, F. H.* "Identification and characterization of a phosphodiesterase that inversely regulates motility and biofilm formation in Vibrio cholerae" J Bacteriol. 2010, 192, 4541-4552. PMCID: PMC2937418
17. Sanchez, L. M.; Lopez, D.; Vesely, B. A.; Della Togna, G.; Gerwick, W. H.; Kyle, D. E.; Linington, R. G.* “Almiramides A-C: Discovery and Development of a New Class of Leishmaniasis Lead CompoundsJ. Med. Chem., 2010, 53, 4187 - 4197. PMCID: PMC4418807
16. Balunas, M. J.; Linington, R. G.; Tidgewell, K.; Fenner, A. M.; Urena, L.-D.; Della Togna, G.; Kyle, D. E.; Gerwick, W. H.* “Dragonamide E, a Modified Linear Lipopeptide from Lyngbya majuscula with Antileishmanial ActivityJ. Nat. Prod., 2010, 73, 60 - 66. PMCID: PMC2834186

2009

15. Peach, K. C.; Linington, R. G.* “New Innovations for an Old Infection: Antimalarial Lead Discovery from Marine Natural Products during the Period 2003–2008Future Medicinal Chemistry, 2009, 1, 593 – 617.
14. Ng, J.; Bandeira, N.; Liu, W.-T.; Ghassemian, M.; Simmons, T. L.; Gerwick, W. H.; Linington, R. G.; Dorrestein, P. C.; Pevzner, P. A.* “Dereplication and De Novo Sequencing of Nonribosomal PeptidesNat. Methods, 2009, 6, 596 – 599. PMCID: PMC2754211
13. Liu, W.-T.; Ng, J.; Meluzzi, D.; Bandeira, N.; Gutierrez, M.; Simmons, T. L.; Schultz, A. W.; Linington, R. G.; Moore, B. S.; Gerwick, W. H.; Pevzner, P. A.; Dorrestein, P. C.* "Interpretation of Tandem Mass Spectra Obtained from Cyclic Nonribosomal Peptides." Anal. Chem. 2009, 81, 4002 - 4009. PMCID: PMC2765223
12. Linington, R. G.; Clark, B. R.; Trimble, E. E.; Almanza, A.; Ureña, L. D.; Kyle, D. E.; Gerwick, W. H.* "Antimalarial Peptides from Marine Cyanobacteria: Isolation and Structural Elucidation of Gallinamide A"  J. Nat. Prod., 2009, 72, 14 - 17. PMCID: PMC2760338

2008 and earlier

11. Linington, R. G.; Edwards, D. J.; Shuman, C. F.; McPhail, K. L.; Matainaho, T.; Gerwick, W. H.* “Symplocamide A, a Potent Cytotoxin and Chymotrypsin Inhibitor from the Marine Cyanobacterium Symploca sp.” J. Nat. Prod., 2008, 71, 22-27. PMCID: PMC2832912
10. Bandeira, N.; Ng, J.; Meluzzi, D.; Linington, R. G.; Dorrestein, P.; Pevzner, P. A.* "De Novo Sequencing of Nonribosomal Peptides." Research in Computational Molecular Biology; Proceedings of the Twelfth Annual International Conference on Computational Molecular Biology (RECOMB 2008), 181 - 195.
9. McPhail, K. L.; Correa, J.; Linington, R. G.; Gonzalez, J.; Ortega-Barria, E.; Capson, T. L.; Gerwick, W. H.* “Antimalarial Linear Lipopeptides from a Panamanian Strain of the Marine Cyanobacterium Lyngbya majuscula. J. Nat. Prod., 2007, 70, 984-988. PMCID: PMC2745555
8. Linington, R. G.; Gonzalez, J.; Ureña, L. D.; Romero, L.; Ortega-Barría, E.; Gerwick, W. H.* “Venturamides A and B: Antimalarial Constituents of the Panamanian Marine Cyanobacterium Oscillatoria sp.” J. Nat. Prod., 2007, 70, 397 – 401. PMID: 17328572
7. Kursar, T. A.; Caballero-George, C. C.; Capson, T. L.; Cubilla-Ríos, L.; Gerwick, W. H.; Heller, M. V.; Ibañez, A.; Linington, R. G.; McPhail, K. L.; Ortega-Barría, E.; Romero, L. I.; Coley, P. D. “Linking Bioprospecting with Sustainable Development and Conservation: the Panama Case” Biodiversity and Conservation, 2007, 16, 2789-2800.
6. Linington, R. G.; Robertson, M.; Gauthier, A.; Finlay, B. B.; MacMiIlan, J.; Molinski, T. F.; van Soest, R.; Andersen, R. J.* “Caminosides B-D, antimicrobial glycolipids isolated from the marine sponge Caminus sphaeroconia” J. Nat. Prod. 2006, 69, 173 - 177 .PMID: 16499312
5. Kursar, T. A.; Caballero, C. C.; Capson T. L.; Cubilla-Rios, L.; Gerwick, W. H.; Ibañez, A.; Linington, R. G.; McPhail, K. L.; Ortega-Barría, E.; Romero, L.; Coley, P. “Securing Economic Benefits and Promoting Conservation through Bioprospecting” BioScience 2006, 56, 1005 -1012.
4. MacMillan, J.; Linington, R. G.; Andersen, R.; Molinski, T. F.* “Stereochemical assignment in acyclic lipids across long distance by circular dichroism: Absolute stereochemistry of the aglycone of caminoside A” Angewandte Chemie 2004, 43, 5946-5951. PMID: 15547902
3. Linington, R. G.; Williams, D. E.; Tahir, A.; van Soest, R.; Andersen, R.* “Latonduines A and B, new alkaloids isolated from the marine sponge Stylissa carteri: Structure elucidation, synthesis, and biogenetic implications” Org. Lett. 2003, 5, 2735 – 2738.PMID: 12868902
2. Linington, R. G.; Robertson, M.; Gauthier, A.; Finlay, B. B.; van Soest, R.; Andersen, R. J.* “Caminoside A, an antimicrobial glycolipid isolated from the marine sponge Caminus sphaeroconia  Org. Lett. 2002, 4, 4089 – 4092. PMID: 12423093
1. Barsby, T.; Linington, R. G.; Andersen, R.* “De novo terpenoid biosynthesis by the dendronotid nudibranch Melibe leonina” Chemoecology, 2002, 12, 199 – 202.

Authors contributed equally.