Target identification forms an important element of drug discovery programs, and is considered an essential component of the development process in many target areas. Our laboratory is interested in employing a range of target identification strategies in order to determine molecular mechanisms of action for test compounds discovered in-house. Among these, compound derivatization and the creation of chemical probes using synthetic organic chemistry is in regular use within the laboratory, and has been used to determine compound modes of action against difficult targets, including protozoan parasites. In addition, we are interested in developing screening technologies that provide insight into compound function at the primary screening stage, and using these data in conjunction with fine-scale profiling methods such as synthetic lethality in yeast to determine molecular mechanisms.

Target identification flowchart